CD127 Rabbit Polyclonal Antibody
Catalog# 0804-9
CD127 Rabbit Polyclonal Antibody
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WB
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IHC-P
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IF-Cell
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FC
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Human
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unconjugated
Overview
Product Name
CD127 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within Human CD127 aa 13-62 / 459.
Species Reactivity
Human
Validated Applications
WB, IHC-P, IF-Cell, FC
Target Molecular Weight
Predicted band size: 52 kDa
Positive Control
K562 cell lysate, human skin tissue lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:1,000-5,000
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IHC-P
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1:200
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IF-Cell
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1:50
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FC
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1:50
Target
Function
The IL-7 cytokine plays a major role in the in vivo maintenance of polyclonal naive and memory T cells, positively regulating the survival, differentiation and proliferation of thymocyte and peripheral T lymphocyte populations. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4,IL-7, IL-9 and IL-15 receptors. Soluble forms of the IL-7 Rα have been reported.
Background References
1. Zhang B et al. CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases. J Exp Med. 2022 Feb
2. Liang KL et al. Circulating IRF8-expressing CD123(+)CD127(+) lymphoid progenitors: key players in human hematopoiesis. Trends Immunol. 2023 Sep
Sequence Similarity
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Post-translational Modification
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
Subcellular Location
Secretion protein, Cell membrane, cytosol, nucleoplasm.
UNIPROT
Synonyms
CD 127 antibody
CD127 antibody
CD127 antigen antibody
CDw127 antibody
IL 7R alpha antibody
IL 7R antibody
IL-7 receptor subunit alpha antibody
IL-7R subunit alpha antibody
IL-7R-alpha antibody
IL-7RA antibody
ExpandImages
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Western blot analysis on K562 cell lysate(A) and human skin tissue lysate (B)using anti- IL-7R-alpha polyclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
CD127 Recombinant Mouse Monoclonal Antibody [PSH12-76]
Application: FC
Reactivity: Human
Conjugate: unconjugated
