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Histone H3 [3-C4]

Product code: EM30605


  • Overview

  • Product name Histone H3
  • Molecular Wt 17 kDa
  • Description The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Species reactivity Human, mouse, rat
  • Tested applications WB,IHC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen peptide
  • Positive control Hela, A431, NIH/3T3, Jurkat, 293, L929, F9, HepG2, MCF-7, mouse brain tissue, mouse kidney tissue, mouse liver tissue, rat liver tissue,human liver tissue,mouse testis tissue.
  • Conjugate Non-conjugated
  • Clone number 3-C4
  • Alternative names H3 histone family, member A antibody
    H3/A antibody
    H31_HUMAN antibody
    H3FA antibody
    Hist1h3a antibody
    HIST1H3B antibody
    HIST1H3C antibody
    HIST1H3D antibody
    HIST1H3E antibody
    HIST1H3F antibody
    HIST1H3G antibody
    HIST1H3H antibody
    HIST1H3I antibody
    HIST1H3J antibody
    histone 1, H3a antibody
    Histone cluster 1, H3a antibody
    Histone H3.1 antibody
    Histone H3/a antibody
    Histone H3/b antibody
    Histone H3/c antibody
    Histone H3/d antibody
    Histone H3/f antibody
    Histone H3/h antibody
    Histone H3/i antibody
    Histone H3/j antibody
    Histone H3/k antibody
    Histone H3/l antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG1
  • Purity ProA affinity purified
  • Subcellular location Nucleus
  • Database links P68431
  • Applications

    WB: 1:5,000
    IHC: 1:100-1:200

  • Publishing research using Histone H3? Please let us know so that we can cite the reference in this datasheet.

  • Wu, W., Wang, S., Liu, Q., Wang, X., Shan, T., & Wang, Y. (2018). Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling. Free Radic Biol Med, 129, 338-353. PMID: 30273672
  • Qing, Z., Xiao-Hui, W., Xi-Mei, W., & Chao-Chun, Z. (2018). Vitamin C deficiency aggravates tumor necrosis factor alpha-induced insulin resistance. Eur J Pharmacol, 829, 1-11 PMID: 29625084
  • Shen, J.et al. (2018). Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and Its Agonists. Circ Res, 122(10), 1395-1408. doi: 10.1161/CIRCRESAHA.117.312418 PMID: 29618597
  • Shu, X., Wang, M., Xu, H., Liu, Y., Huang, J., Yao, Z., & Zhang, L. (2017). Extracts of Salvia-Nelumbinis Naturalis Ameliorate Nonalcoholic Steatohepatitis via Inhibiting Gut-Derived Endotoxin Mediated TLR4/NF-kappaB Activation. Evid Based Complement Alternat Med, 2017, 9208314. PMID: 28831287
  • Wang, K., Jin, X., Chen, Y., Song, Z., Jiang, X., Hu, F., . . . Topping, D. L. (2016). Polyphenol-Rich Propolis Extracts Strengthen Intestinal Barrier Function by Activating AMPK and ERK Signaling. Nutrients, 8(5). PMID: 27164138
  • Wang, J., Zhang, Y., Weng, W., Qiao, Y., Ma, L., Xiao, W., . . . Sun, F. (2013). Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer. J Biol Chem, 288(47), 33667-33681. doi: 10.1074/jbc.M113.503292 PMID: 24089522

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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