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Annexin V [JF50-11]

Product code: ET1702-62

  • Overview

  • Product name Annexin V
  • Molecular Wt 36 kDa
  • Description The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain, which binds phospholipids in a Ca2+-dependent manner, and a unique amino-terminal region, which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. For example, the crystal structure of Annexin III has suggested a hydrophilic amino-terminus with possible Ca2+ channel activity. Similarly, Annexin V has ion channel properties. Annexin IV, also referred to as endonexin, functions to regulate Cl-flux by mediating calmodulin kinase II (CaMKII) activity and Annexin V has been shown to regulate PKC activity. Annexin V is ubiquitously expressed at high levels in tissues and cells grown in tissue culture, while Annexin VIII exhibits a more limited distribution. Where co-expressed in the same tissues, Annexin VIII is often expressed at a 100-fold lower level than Annexin V. However, Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells, which may relate to its role in hematopoietic cell differentiation.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC/IF,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control JAR, A431, Hela, HepG2, human liver tissue, mouse liver tissue, mouse brain tissue, human lung tissue.
  • Conjugate Non-conjugated
  • Clone number JF50-11
  • Alternative names Anchorin CII antibody
    Annexin 5 antibody
    Annexin A5 antibody
    Annexin V antibody
    Annexin-5 antibody
    ANX A5 antibody
    ANX5 antibody
    ANXA5 antibody
    ANXA5_HUMAN antibody
    Calphobindin I antibody
    CBP-I antibody
    Endonexin II antibody
    ENX2 antibody
    Lipocortin V antibody
    PAP I antibody
    PAP-I antibody
    Placental anticoagulant protein 4 antibody
    Placental anticoagulant protein I antibody
    PLACENTAL PROTEIN 4 antibody
    Pp4 antibody
    Thromboplastin inhibitor antibody
    VAC-alpha antibody
    Vascular anticoagulant-alpha antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, endothelial microparticle, membrane.
  • Database links P08758(Human)
  • Applications

    WB: 1:1,000
    FC: 1:50-1:100
    ICC: 1:100-1:500

  • Publishing research using Annexin V? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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