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PMS2 [SY08-09]

Product code: ET1605-1

  • Overview

  • Product name PMS2
  • Molecular Wt 96 kDa
  • Description Component of the post-replicative DNA mismatch repair system (MMR). It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
  • Species reactivity Human
  • Tested applications WB,ICC/IF,IHC,IP,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Hela, human breast carcinoma tissue, human colon cancer tissue.
  • Conjugate Non-conjugated
  • Clone number SY08-09
  • Alternative names DNA mismatch repair gene homologue antibody
    DNA mismatch repair protein PMS2 antibody
    H_DJ0042M02.9 antibody
    HNPCC4 antibody
    Mismatch repair endonuclease PMS2 antibody
    Mismatch repair gene PMSL2 antibody
    PMS 2 antibody
    PMS1 protein homolog 2 antibody
    PMS2 antibody
    PMS2 postmeiotic segregation increased 2 antibody
    PMS2 postmeiotic segregation increased 2 (S. cerevisiae) antibody
    PMS2_HUMAN antibody
    PMS2CL antibody
    PMSL2 antibody
    Postmeiotic segregation increased, S. cerevisiae, 2 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/ml.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A purified.
  • Subcellular location Nucleus.
  • Database links SwissProt: P54278 Human
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • Publishing research using PMS2? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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