The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.
Recombinant Rabbit Monoclonal Antibody
Human lung tissue, human colon cancer tissue, human kidney tissue, human gastric carcinoma tissue, mouse colon tissue, mouse kidney tissue.
42C antibody AA409961 antibody AL024248 antibody Annexin II ligand antibody Annexin II ligand, calpactin I, light polypeptide antibody Annexin II tetramer (AIIt) p11 subunit antibody Annexin II, light chain antibody ANX2L antibody ANX2LG antibody Ca antibody CAL12 antibody CAL1L antibody Calpactin I light chain antibody Calpactin I, p11 subunit antibody Calpactin-1 light chain antibody Cellular ligand of annexin II antibody CLP11 antibody GP11 antibody MGC111133 antibody Nerve growth factor-induced protein 42C antibody OTTHUMP00000015269 antibody OTTHUMP00000015270 antibody p10 antibody p10 protein antibody p11 antibody Protein S100 A10 antibody Protein S100-A10 antibody S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) antibody S100 calcium binding protein A10 (calpactin) antibody S100 calcium binding protein A10 antibody S100 calcium-binding protein A10 antibody S100a10 antibody S10AA_HUMAN antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
WB: 1:1,000-1:2,000 IHC: 1:50-1:200
Fig1: Western blot analysis of S100A10 on human lung lysates using anti-S100A10 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-S100A10 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-S100A10 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-S100A10 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-S100A10 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-S100A10 antibody. Counter stained with hematoxylin.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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