The catenins, α, β and γ, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. β-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. β-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, binds with α-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP? associates with catenin/cadherin complexes and may regulate complex signaling.
Human, Mouse, Rat
Recombinant Rabbit Monoclonal Antibody
A431, MCF-7, Hela, mouse stomach tissue.
ARVD 12 antibody ARVD12 antibody Catenin (cadherin associated protein), gamma 80kDa antibody catenin (cadherin-associated protein) gamma (80kD) antibody Catenin gamma antibody CTNNG antibody Desmoplakin 3 antibody Desmoplakin III antibody Desmoplakin-3 antibody Desmoplakin3 antibody DesmoplakinIII antibody DP 3 antibody DP III antibody DP3 antibody DPIII antibody gamma catenin antibody Junction plakoglobin antibody JUP antibody OTTHUMP00000164732 antibody OTTHUMP00000164735 antibody OTTHUMP00000164738 antibody PDGB antibody PKGB antibody PLAK_HUMAN antibody PLAKOGLOBIN antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Cell junction, Cytoplasm, Membrane.
WB: 1:1,000-1:2,000 ICC: 1:100-1:500 IHC: 1:50-1:200 FC: 1:50-1:100
Fig1: Western blot analysis of gamma Catenin on Hela cells lysates using anti-gamma Catenin antibody at 1/1,000 dilution.
Fig2: ICC staining gamma Catenin in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining gamma Catenin in MCF-7 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: ICC staining gamma Catenin in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-gamma Catenin antibody. Counter stained with hematoxylin.
Fig6: Flow cytometric analysis of Hela cells with gamma Catenin antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
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