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Transferrin Receptor (CD71) [JF0956]

Product code: ET1702-06


  • Overview

  • Product name Transferrin Receptor (CD71)
  • Molecular Wt 85 kDa
  • Description CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC,IP,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control Mouse placenta tissue, rat brain tissue, human lung cancer tissue, mouse brain tissue, mouse placenta tissue.
  • Conjugate Non-conjugated
  • Clone number JF0956
  • Alternative names CD 71 antibody
    CD71 antibody
    CD71 antigen antibody
    IMD46 antibody
    OTTHUMP00000208523 antibody
    OTTHUMP00000208524 antibody
    OTTHUMP00000208525 antibody
    p90 antibody
    sTfR antibody
    T9 antibody
    TFR 1 antibody
    TfR antibody
    TfR1 antibody
    TFR1_HUMAN antibody
    TFRC antibody
    TR antibody
    Transferrin receptor (p90 CD71) antibody
    Transferrin receptor protein 1, serum form antibody
    Trfr antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane, Melanosome, Secreted.
  • Database links P02786(Human)
    Q62351(Mouse)
    Q99376(Rat)
  • Applications

    WB: 1:1,000-1:2,000
    FC: 1:50-1:100
    IHC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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