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JNK1+JNK3 [JJ08-86]

Product code: ET1701-47

  • Overview

  • Product name JNK1+JNK3
  • Molecular Wt 48 kDa
  • Description c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IP
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control NIH/3T3, PC-12.
  • Conjugate Non-conjugated
  • Clone number JJ08-86
  • Alternative names c Jun N terminal kinase 3 antibody
    c Jun N-terminal kinase 1 antibody
    JNK 46 antibody
    JNK antibody
    JNK1 antibody
    JNK1A2 antibody
    JNK21B1/2 antibody
    JNK3 alpha protein kinase antibody
    JNK3 antibody
    JNK3A antibody
    JUN N terminal kinase antibody
    MAP kinase 10 antibody
    MAP kinase 8 antibody
    MAP kinase p49 3F12 antibody
    MAPK 10 antibody
    MAPK10 antibody
    MAPK8 antibody
    Mitogen activated protein kinase 10 antibody
    Mitogen activated protein kinase 8 antibody
    Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody
    Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody
    p493F12 antibody
    p54bSAPK antibody
    PRKM10 antibody
    PRKM8 antibody
    SAPK1 antibody
    SAPK1b antibody
    SAPK1c antibody
    Stress activated protein kinase 1 antibody
    Stress activated protein kinase 1b antibody
    Stress activated protein kinase 1c antibody
    Stress activated protein kinase beta antibody
    Stress activated protein kinase JNK3 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Nucleus, Membrane, Mitochondrion.
  • Database links P45983(Human)
  • Applications

    WB: 1:1,000-1:2,000

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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