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PD-L1 [JJ08-95]

Product code: ET1701-41

  • Overview

  • Product name PD-L1
  • Molecular Wt 33 kDa (Predicted band size)
  • Description Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Synthetic peptide within Human PD-L1 aa 200-230 (Extracellular).
  • Positive control A549 cell lysate, MCF-7 cell lysate, mouse placenta tissue lysate, mouse lung tissue lysate, human non-small cell lung cancer tissue.
  • Conjugate Non-conjugated
  • Clone number JJ08-95
  • Alternative names B7 H antibody
    B7 H1 antibody
    B7 homolog 1 antibody
    B7-H1 antibody
    B7H antibody
    B7H1 antibody
    CD 274 antibody
    CD274 antibody
    CD274 antigen antibody
    CD274 molecule antibody
    MGC142294 antibody
    MGC142296 antibody
    OTTHUMP00000021029 antibody
    PD L1 antibody
    PD-L1 antibody
    PD1L1_HUMAN antibody
    PDCD1 ligand 1 antibody
    PDCD1L1 antibody
    PDCD1LG1 antibody
    PDL 1 antibody
    PDL1 antibody
    Programmed cell death 1 ligand 1 antibody
    Programmed death ligand 1 antibody
    RGD1566211 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A purified.
  • Subcellular location Cell membrane, Endomembrane system.
  • Database links SwissProt: Q9NZQ7 Human
    SwissProt: Q9EP73 Mouse
  • Applications

    WB: 1:500-1:2,000
    IHC: 1:50-1:200

  • Publishing research using PD-L1? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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