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JNK3 [SD082-09]

Product code: ET1612-68

  • Overview

  • Product name JNK3
  • Molecular Wt 53 kDa
  • Description c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC/IF,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control 293T, NIH/3T3, Hela, SH-SY-5Y.
  • Conjugate Non-conjugated
  • Clone number SD082-09
  • Alternative names c Jun kinase 3 antibody
    c-Jun N-terminal kinase 3 antibody
    cJun N terminal kinase 3 antibody
    FLJ12099 antibody
    FLJ33785 antibody
    JNK3 alpha protein kinase antibody
    JNK3 antibody
    JNK3A antibody
    MAP kinase 10 antibody
    MAP kinase antibody
    MAP kinase p49 3F12 antibody
    MAPK 10 antibody
    Mapk10 antibody
    MGC50974 antibody
    mitogen activated protein kinase 10 antibody
    Mitogen-activated protein kinase 10 antibody
    MK10_HUMAN antibody
    p493F12 antibody
    p54bSAPK antibody
    PRKM10 antibody
    protein kinase mitogen activated 10 antibody
    SAPK1b antibody
    Stress activated protein kinase 1b antibody
    stress activated protein kinase beta antibody
    Stress activated protein kinase JNK3 antibody
    Stress-activated protein kinase JNK3 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Membrane, Nucleus, Mitochondrion.
  • Database links P53779(Human)
  • Applications

    WB: 1:500
    FC: 1:50-1:100
    ICC: 1:100-1:500

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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