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Integrin beta-1 [SR30-03]

Product code: ET1602-10


  • Overview

  • Product name Integrin beta-1
  • Molecular Wt 150 kDa
  • Description Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control Human liver tissue, human liver cancer tissue, human colon cancer tissue, mouse colon tissue, mouse stomach tissue.
  • Conjugate Non-conjugated
  • Clone number SR30-03
  • Alternative names beta1 integrin antibody
    CD29 antibody
    Fibronectin receptor subunit beta antibody
    FNRB antibody
    Glycoprotein IIa antibody
    GP IIa antibody
    GPIIA antibody
    Integrin beta-1 antibody
    integrin VLA-4 beta subunit antibody
    Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody
    ITB1_HUMAN antibody
    ITGB1 antibody
    MDF2 antibody
    MSK12 antibody
    OTTHUMP00000019420 antibody
    Very late activation protein, beta polypeptide antibody
    VLA BETA antibody
    VLA-4 subunit beta antibody
    VLA-BETA antibody
    VLAB antibody
    VLAbeta antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane, Cell projection, Cleavage furrow
  • Database links P05556(Human)
    P09055(Mouse)
    P49134(Rat)
  • Applications

    WB: 1:1,000-1:2,000
    IHC:1:50-1:200
    FC: 1:50-1:100

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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