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LMAN1 [JE55-19]

Product code: ET7110-98


  • Overview

  • Product name LMAN1
  • Molecular Wt 58 kDa
  • Description The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. MCFD2 is the second gene that leads to combined deficiency of factor V-factor VIII. ERGIC-53 and MCFD2 form a protein complex and serve as a cargo receptor to transport FV and FVIII from the ER to the ERGIC and then the Golgi, as illustrated here.
  • Species reactivity Human,Mouse,Rat
  • Tested applications WB,IHC-P
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Synthetic peptide within N-terminal Human LMAN1.
  • Positive control NIH/3T3 cell lysate, human placenta tissue lysate, HUVEC cell lysate, rat brain tissue, mouse kidney tissue, mouse testis tissue.
  • Conjugate Non-conjugated
  • Clone number JE55-19
  • Alternative names Endoplasmic reticulum golgi intermediate compartment protein 53 antibody
    ER-Golgi intermediate compartment 53 kDa protein antibody
    ERGIC-53 antibody
    ERGIC53 antibody
    ERGIC53 like protein antibody
    F5F8D antibody
    FMFD1 antibody
    Gp58 antibody
    Intracellular mannose specific lectin antibody
    Intracellular mannose-specific lectin MR60 antibody
    Lectin mannose binding 1 antibody
    Lectin mannose-binding 1 antibody
    Lman1 antibody
    LMAN1 like protein antibody
    LMAN1_HUMAN antibody
    MCFD1 antibody
    MR60 antibody
    Protein ERGIC-53 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A affinity purified.
  • Subcellular location Golgi apparatus membrane, endoplasmic reticulum membrane, endoplasmic reticulum-golgi intermediate compartment membrane.
  • Database links SwissProt: P49257 Human
    SwissProt: Q9D0F3 Mouse
    SwissProt: Q62902 Rat
  • Applications

    WB:1:500-1:1,000
    IHC-P:1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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