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TEF1 [JE52-71]

Product code: ET7111-04


  • Overview

  • Product name TEF1
  • Molecular Wt 48 kDa
  • Description Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
  • Species reactivity Human,Mouse,Rat
  • Tested applications WB,ICC,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Synthetic peptide within N-terminal Human TEF1.
  • Positive control SiHa cell lysate, Hela cell lysate, A549, MG-63, SiHa, human colon cancer tissue, rat skeletal muscle tissue.
  • Conjugate Non-conjugated
  • Clone number JE52-71
  • Alternative names AA antibody
    Atrophia areata peripapillary chorioretinal degeneration antibody
    NTEF 1 antibody
    NTEF-1 antibody
    NTEF1 antibody
    Protein GT IIC antibody
    Protein GT-IIC antibody
    REF 1 antibody
    REF1 antibody
    SV40 transcriptional enhancer factor antibody
    TCF 13 antibody
    TCF-13 antibody
    TCF13 antibody
    TEA domain family member antibody
    TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody
    TEA domain family member 1 antibody
    TEAD 1 antibody
    TEAD 1 protein antibody
    TEAD-1 antibody
    TEAD1 antibody
    TEAD1 protein antibody
    TEAD1_HUMAN antibody
    TEF 1 antibody
    TEF1 antibody
    Transcription factor 13 (SV40 transcriptional enhancer factor) antibody
    Transcription factor 13 antibody
    Transcriptional enhancer factor 1 antibody
    Transcriptional enhancer factor TEF-1 antibody
    Transcriptional enhancer factor TEF1 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/ml.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A affinity purified.
  • Subcellular location Nucleus.
  • Database links SwissProt:P28347 Human
    SwissProt:P30051 Mouse
  • Applications

    WB:1:500-1:1,000
    ICC:1:50-1:100
    IHC:1:50-1:200

  • Publishing research using TEF1? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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