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CD283 [6F3G4]

Product code: EM1712-01

  • Overview

  • Product name CD283
  • Molecular Wt 103.8kDa
  • Description The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
  • Species reactivity Human
  • Tested applications WB,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Purified recombinant fragment of human CD283 (AA: 24-217) expressed in E. Coli.
  • Positive control HL-60 cells
  • Conjugate Non-conjugated
  • Clone number 6F3G4
  • Alternative names CD283 antibody
    CD283 antigen antibody
    IIAE2 antibody
    TLR 3 antibody
    Tlr3 antibody
    TLR3_HUMAN antibody
    Toll Like Receptor 3 antibody
    Toll-like receptor 3 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS with 0.05% sodium azide.
  • Isotype IgG1
  • Purity Protein G purified.
  • Subcellular location Endoplasmic reticulum membrane. Endosome membrane.
  • Database links SwissProt:O15455 Human
  • Applications

    WB: 1:500-1:2,000
    FC: 1:100-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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