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EZH1 [3B6B9]

Product code: EM1711-99

  • Overview

  • Product name EZH1
  • Molecular Wt 85.3kDa
  • Description The polycomb group (PcG) proteins are involved in maintaining the silenced state of multiple developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis. Enhancer of zest homolog 1 (Ezh1), is a member of this large protein family and a subunit of the polycomb repressor complex 2 (PRC2), also containing SUZ12 and EED. Ezh1 and its paralog Ezh2 are mutually exclusive catalytic subunits of the PRC2 complex, which functions to mono-, di-, and tri-methylated Lys27 on histone H3, a mark that is associated with transcriptional repression. While EZH1 is less abundant than EZH2, it is still required for cell identity and self-renewal of embryonic stem cells. Ezh1 is also required for hematopoietic stem cell maintenance and functions to prevent a senescence-like cell cycle arrest. Ezh1 is required for myogenic differentiation and hepatocyte homeostasis and regeneration. While many studies have implicated Ezh2 in multiple types of cancer, a potential role for Ezh1 is less understood. However, several studies have shown dual inhibitors of Ezh1/Ezh2 to be more effective than Ezh2-specific inhibitors in treatment of multiple myeloma, prostate cancer, diffuse large B-cell lymphoma, and leukemia, suggesting an important role for Ezh1 in cancer.
  • Species reactivity Human
  • Tested applications WB,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Purified recombinant fragment of human EZH1 (AA: 135-294) expressed in E. Coli.
  • Positive control HepG2 and Hela cell lysate, Hela cells
  • Conjugate Non-conjugated
  • Clone number 3B6B9
  • Alternative names Enhancer of zeste homolog 1 (Drosophila) antibody
    Enhancer of zeste homolog 1 antibody
    ENX-2 antibody
    ENX2 antibody
    Ezh1 antibody
    EZH1_HUMAN antibody
    Histone-lysine N-methyltransferase EZH1 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS with 0.05% sodium azide.
  • Isotype IgG1
  • Purity Protein G purified.
  • Subcellular location Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
  • Database links SwissProt:Q92800 Human
  • Applications

    WB: 1:500-1:2,000
    FC: 1:100-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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