Location: Home >Product >Product Detail

DDX58 [B1-G6]

Product code: EM1707-58

  • Overview

  • Product name DDX58
  • Molecular Wt 107 kDa
  • Description The innate immune system senses viral infection by recognizing many different viral components and triggering specific antiviral responses. Intracellular double-stranded RNA (dsRNA) is a major sign of replication for many viruses. Retinoic acid inducible gene I (RIG-I) is a 925 amino acid, interferon-inducible cellular DExD/H box RNA helicase that activates type I interferon (IFN), an important effector of the innate immune system that is sensitive to these dsRNA viruses. dsRNA is normally present in very low quantities in cells, so when a virus is present, the elevated levels of dsRNA act as a sign telling RIG-I to activate the production of IFN. RIG-I does this by using its helicase domain to bind to viral dsRNA, thus transmitting the activation signal for IFN through IkB kinase-related kinases and inducing IFN expression. RIG-I is expressed in the cytoplasm of fibroblasts and conventional dendritic cells and can distinguish between many different RNA viruses.
  • Species reactivity Human
  • Tested applications WB,IHC,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Human DDX58 recombinant protein, DDX58-hIgGFc transfected HEK293 cell lysate, Hela, MCF-7.
  • Conjugate Non-conjugated
  • Clone number B1-G6
  • Alternative names Ddx58 antibody
    DDX58_HUMAN antibody
    DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody
    DEAD (Asp Glu Ala Asp/His) box polypeptide antibody
    DEAD box protein 58 antibody
    DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody
    DKFZp434J1111 antibody
    DKFZp686N19181 antibody
    FLJ13599 antibody
    Probable ATP dependent RNA helicase DDX58 antibody
    Probable ATP-dependent RNA helicase DDX58 antibody
    Retinoic acid inducible gene 1 protein antibody
    Retinoic acid-inducible gene 1 protein antibody
    Retinoic acid-inducible gene I protein antibody
    RIG I antibody
    Rig-1 antibody
    RIG-I antibody
    RIG1 antibody
    rigi antibody
    RLR 1 antibody
    RNA helicase antibody
    RNA helicase RIG I antibody
    SGMRT2 antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgM
  • Purity Protein A purified.
  • Subcellular location Cytoplasm
  • Database links O95786(Human)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:100-1:500
    FC: 1:100-1:200

  • Publishing research using DDX58? Please let us know so that we can cite the reference in this datasheet.

  • Data sorting...

Choose your product,application and species below,then click "Create".

On the next page you can complete and submit your review.

  • * Code NO.
  • * Application
  • *Sample
  • Species Tested
  • Against
  • Choose text
  • Content

Leave us a review

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols
Add to cart successfully.