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DDX58 [B1-G6]

Product code: EM1707-58


  • Overview

  • Product name DDX58
  • Molecular Wt 107 kDa
  • Description The innate immune system senses viral infection by recognizing many different viral components and triggering specific antiviral responses. Intracellular double-stranded RNA (dsRNA) is a major sign of replication for many viruses. Retinoic acid inducible gene I (RIG-I) is a 925 amino acid, interferon-inducible cellular DExD/H box RNA helicase that activates type I interferon (IFN), an important effector of the innate immune system that is sensitive to these dsRNA viruses. dsRNA is normally present in very low quantities in cells, so when a virus is present, the elevated levels of dsRNA act as a sign telling RIG-I to activate the production of IFN. RIG-I does this by using its helicase domain to bind to viral dsRNA, thus transmitting the activation signal for IFN through IkB kinase-related kinases and inducing IFN expression. RIG-I is expressed in the cytoplasm of fibroblasts and conventional dendritic cells and can distinguish between many different RNA viruses.
  • Species reactivity Human
  • Tested applications WB,IHC,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Human DDX58 recombinant protein, DDX58-hIgGFc transfected HEK293 cell lysate, Hela, MCF-7.
  • Conjugate Non-conjugated
  • Clone number B1-G6
  • Alternative names Ddx58 antibody
    DDX58_HUMAN antibody
    DEAD (Asp Glu Ala Asp) box polypeptide 58 antibody
    DEAD (Asp Glu Ala Asp/His) box polypeptide antibody
    DEAD box protein 58 antibody
    DEAD/H (Asp Glu Ala Asp/His) box polypeptide RIG1 antibody
    DKFZp434J1111 antibody
    DKFZp686N19181 antibody
    FLJ13599 antibody
    Probable ATP dependent RNA helicase DDX58 antibody
    Probable ATP-dependent RNA helicase DDX58 antibody
    Retinoic acid inducible gene 1 protein antibody
    Retinoic acid-inducible gene 1 protein antibody
    Retinoic acid-inducible gene I protein antibody
    RIG I antibody
    Rig-1 antibody
    RIG-I antibody
    RIG1 antibody
    rigi antibody
    RLR 1 antibody
    RNA helicase antibody
    RNA helicase RIG I antibody
    SGMRT2 antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgM
  • Purity Protein A purified.
  • Subcellular location Cytoplasm
  • Database links O95786(Human)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:100-1:500
    FC: 1:100-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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