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DHX58 [A3-A6]

Product code: EM1707-41


  • Overview

  • Product name DHX58
  • Molecular Wt 77 kDa
  • Description Helicases are enzymes that catalyze the separation of double stranded DNA or RNA by utilizing ATP. LGP2, also known as probable ATP-dependent RNA helicase DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain.
  • Species reactivity Human
  • Tested applications WB,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Human DHX58 recombinant protein, DHX58-hIgGFc transfected HEK293 cell lysate, Hela.
  • Conjugate Non-conjugated
  • Clone number A3-A6
  • Alternative names D11LGP2 antibody
    D11lgp2e antibody
    DEXH (Asp Glu X His) box polypeptide 58 antibody
    DEXH box polypeptide 58 antibody
    DHX 58 antibody
    DHX58 antibody
    DHX58_HUMAN antibody
    LGP 2 antibody
    LGP2 antibody
    Ortholog of mouse D11lgp2 antibody
    Probable ATP dependent helicase LGP2 antibody
    Probable ATP dependent RNA helicase DHX58 antibody
    Probable ATP-dependent helicase LGP2 antibody
    Probable ATP-dependent RNA helicase DHX58 antibody
    Protein D11Lgp2 homolog antibody
    RIG-I-like receptor LGP2 antibody
    RLR antibody
    RNA helicase LGP2 antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG2b
  • Purity Protein A purified.
  • Subcellular location Cytoplasm
  • Database links Q96C10(Human)
  • Applications

    WB: 1:500-1:2,000
    FC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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