Helicases are enzymes that catalyze the separation of double stranded DNA or RNA by utilizing ATP. LGP2, also known as probable ATP-dependent RNA helicase DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain.
Mouse Monoclonal Antibody
Human DHX58 recombinant protein, DHX58-hIgGFc transfected HEK293 cell lysate, Hela.
DEXH (Asp Glu X His) box polypeptide 58 antibody
DEXH box polypeptide 58 antibody
DHX 58 antibody
LGP 2 antibody
Ortholog of mouse D11lgp2 antibody
Probable ATP dependent helicase LGP2 antibody
Probable ATP dependent RNA helicase DHX58 antibody
Probable ATP-dependent helicase LGP2 antibody
Probable ATP-dependent RNA helicase DHX58 antibody
Protein D11Lgp2 homolog antibody
RIG-I-like receptor LGP2 antibody
RNA helicase LGP2 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Fig1: Western blot analysis of DHX58 on human DHX58 recombinant protein using anti-DHX58 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of DHX58 on HEK293 (1) and DHX58-hIgGFc transfected HEK293 (2) cell lysate using anti-DHX58 antibody at 1/1,000 dilution.
Fig3: Flow cytometric analysis of Hela cells with DHX58 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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