MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
Mouse Monoclonal Antibody
Human TIP60 recombinant protein, TIP60-hIgGFc transfected HEK293 cell lysate, Hela.
60 kDa Tat interactive protein antibody
60 kDa Tat-interactive protein antibody
cPLA(2) interacting protein antibody
cPLA(2)-interacting protein antibody
cPLA2 interacting protein antibody
Histone acetyltransferase HTATIP antibody
Histone acetyltransferase KAT5 antibody
HIV 1 Tat interactive protein antibody
HIV 1 Tat interactive protein, 60kDa antibody
HIV-1 Tat interactive protein antibody
K(lysine) acetyltransferase 5 antibody
K-acetyltransferase 5 antibody
Lysine acetyltransferase 5 antibody
Tat interacting protein, 60kDa antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Fig1: Western blot analysis of TIP60 on human TIP60 recombinant protein using anti-TIP60 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of TIP60 on HEK293 (1) and TIP60-hIgGFc transfected HEK293 (2) cell lysate using anti-TIP60 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of TIP60 on Hela cell lysate using anti-TIP60 antibody at 1/1,000 dilution.
Fig4: Flow cytometric analysis of Hela cells with TIP60 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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