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Plectin [SY29-04]

Product code: ET1607-80

  • Overview

  • Product name Plectin
  • Molecular Wt 531 kDa
  • Description Plectin is an abundant cytoskeletal protein that is involved in cytoplasm stabilization. Plectin has been shown to crosslink intermediate filaments to microtubules and microfilaments, and to anchor intermediate filaments to the plasma and nuclear membranes. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions. Plectin is also a substrate for p34cdc2 kinase. Several alternative splice isoforms of plectin are known to exist. Mutations in human plectin are known to cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD).
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC,IP
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control Rat skeletal muscle tissue, mouse skeletal muscle tissue.
  • Conjugate Non-conjugated
  • Clone number SY29-04
  • Alternative names EBS1 antibody
    EBSO antibody
    HD1 antibody
    Hemidesmosomal protein 1 antibody
    PCN antibody
    pleC antibody
    PLEC_HUMAN antibody
    PLEC1 antibody
    PLEC1b antibody
    Plectin 1 antibody
    Plectin 1 intermediate filament binding protein 500kDa antibody
    Plectin 6 antibody
    Plectin antibody
    Plectin-1 antibody
    PLTN antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Cell junction.
  • Database links Q15149(Human)
  • Applications

    WB: 1:1,000
    IHC: 1:100-1:500

  • Publishing research using Plectin? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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