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Phospho-P38 MAPK (Thr180 + Tyr182)

Product code: ER1903-01

  • Overview

  • Product name Phospho-P38 MAPK (Thr180 + Tyr182)
  • Molecular Wt 42 kDa
  • Description The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC,FC
  • Antibody type Rabbit polyclonal Antibody
  • Immunogen KLH conjugated Synthesised phosphopeptide derived from human p38 MAPK around the phosphorylation site of Thr180/Tyr182: M(p-T)G(p-Y)VA.
  • Positive control Mouse muscle tissue, rat muscle tissue, rat brain tissue, mouse brain tissue, human placenta tissue, HepG2.
  • Conjugate Non-conjugated
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity ProA affinity purified.
  • Subcellular location Cytoplasm. Nucleus.
  • Database links SwissProt: Q16539 Human
    SwissProt: P47811 Mouse
    SwissProt: P70618 Rat
  • Applications

    WB: 1:500-1:2,000
    IHC: 1:400-1:800
    FC: 1:50

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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