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ALOX12

Product code: ER1903-58


  • Overview

  • Product name ALOX12
  • Molecular Wt 76 KDa
  • Description Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750,
  • Species reactivity Human, Mouse, Rat, Cow
  • Tested applications WB
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen KLH conjugated synthetic peptide derived from human 12 Lipoxygenase 101-200/663
  • Positive control Expressed in vascular smooth muscle cells.
  • Conjugate Non-conjugated
  • Alternative names 12 Lox
    12(S) lipoxygenase
    12S LOX
    Alox 12
    Alox12L
    Alox15
    Arachidonate 12 lipoxygenase 12S type
    Arachidonate 12 lipoxygenase
    Arachidonate 12 lipoxygenase leukocyte type
    Arachidonate 12 lipoxygenase, 12S type
    Arachidonate 12 lipoxygenase, leukocyte type
    EC1.13.11.31
    LOG 12
    LOG12
    Platelet type 12 lipoxygenase
    Platelet type lipoxygenase 12
    P-12-LOX
    LOX12_HUMAN
    12 Lipoxygenase.
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity affinity purified by Protein A
  • Subcellular location Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
  • Database links SwissProt: P18054 Human
  • Applications

    WB:1:500-2000

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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