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IRAKM [SN64-07]

Product code: ET1611-11


  • Overview

  • Product name IRAKM
  • Molecular Wt 61 kDa
  • Description Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. An IL-1-dependent kinase termed IRAK-1 (for IL-1 receptor- associated kinase 1) coimmunoprecipitates with activated IL-1RI and is implicated as an upstream mediator of NFkB activation. A related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFkB. IRAK-2 is a proximal mediator of IL1, a component of the IL1R signaling complex, and is required for IL1R-induced NFkB activation. IRAK-4, like IRAK-1 and Pelle, has auto- and cross-phosphorylation kinase activity. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells. IRAK-M mRNA transcripts are found predominantly in PBL and the monocytic cell lines U937 and THP-1.
  • Species reactivity Human
  • Tested applications WB,IP
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control Human placenta tissue, human thyroid tissue.
  • Conjugate Non-conjugated
  • Clone number SN64-07
  • Alternative names ASRT5 antibody
    IL 1 receptor associated kinase M antibody
    IL-1 receptor-associated kinase M antibody
    IL1 receptor associated kinase M antibody
    Interleukin 1 receptor associated kinase 3 antibody
    Interleukin 1 receptor associated kinase M antibody
    Interleukin-1 receptor-associated kinase 3 antibody
    IRAK M antibody
    IRAK-3 antibody
    IRAK-M antibody
    Irak3 antibody
    IRAK3_HUMAN antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Nucleus.
  • Database links Q9Y616(Human)
  • Applications

    WB: 1:1,000-1:2,000

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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