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CYLD

Product code: ER1906-97


  • Overview

  • Product name CYLD
  • Molecular Wt 105 KDa
  • Description Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis
  • Species reactivity Human, Mouse, Rat, Chicken, Cow, Horse
  • Tested applications WB,IHC-P
  • Antibody type Rabbit polyclonal Antibody
  • Immunogen KLH conjugated synthetic peptide derived from human cylindromatosis 1 501-600/956
  • Positive control Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.
  • Conjugate Non-conjugated
  • Alternative names CDMT
    cylindromatosis (turban tumor syndrome)
    cylindromatosis 1
    Deubiquitinating enzyme CYLD
    EAC
    HSPC057
    KIAA0849
    turban tumor syndrome
    Ubiquitin thiolesterase CYLD
    Ubiquitin-specific processing protease CYLD
    CYLD_HUMAN
    Ubiquitin carboxyl-terminal hydrolase CYLD
    CYLD
    BRSS
    CDMT
    CYLD1
    CYLDI
    EAC
    MFT
    MFT1
    SBS
    TEM
    USPL2.
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity affinity purified by Protein A
  • Subcellular location Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase.
  • Database links SwissProt: Q9NQC7 Human
  • Applications

    WB:1:500-2000
    IHC-P:1:400-800

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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