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ENPP1

Product code: ER1908-13


  • Overview

  • Product name ENPP1
  • Molecular Wt 100 KDa
  • Description Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
  • Species reactivity Human, Mouse, Rat, Dog, Pig, Horse, Rabbit
  • Tested applications WB
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen KLH conjugated synthetic peptide derived from human ENPP1 41-140/925
  • Positive control Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis.
  • Conjugate Non-conjugated
  • Alternative names Alkaline phosphodiesterase 1
    ARHR2
    E-NPP 1
    Ectonucleotide pyrophosphatase/phosphodiesterase 1
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    ENPP1_HUMAN
    Ly 41 antigen
    M6S1
    Membrane component chromosome 6 surface marker 1
    NPP1
    NPPase
    NPPS
    Nucleotide pyrophosphatase
    PC-1
    PCA1
    PDNP1
    Phosphodiesterase I/nucleotide pyrophosphatase 1
    Plasma cell membrane glycoprotein 1
    Plasma-cell membrane glycoprotein PC-1.
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity affinity purified by Protein A
  • Subcellular location Membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.
  • Database links SwissProt: P22413 Human
  • Applications

    WB:1:500-2000

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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