Location: Home >Product >Product Detail

Exonuclease 1

Product code: ER1908-42


  • Overview

  • Product name Exonuclease 1
  • Molecular Wt 94 KDa
  • Description 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
  • Species reactivity Human, Mouse, Rat, Chimpanzee, Macaque Monkey, Gorilla, Chinese Hamster, Orangu
  • Tested applications WB,IHC-P,FC
  • Antibody type Rabbit polyclonal Antibody
  • Immunogen KLH conjugated synthetic peptide derived from human Exonuclease 1 31-130/846
  • Positive control Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.
  • Conjugate Non-conjugated
  • Alternative names exo1
    EXO1_HUMAN
    ExoI
    Exonuclease 1
    Exonuclease I
    Exonuclease1
    HEX1
    hExo I
    hExo1
    hExoI
    Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1.
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity affinity purified by Protein A
  • Subcellular location Nucleus. Colocalizes with PCNA to discrete nuclear foci in S-phase.
  • Database links SwissProt: Q9UQ84 Human
  • Applications

    WB:1:500-2000
    IHC-P:1:400-800
    FC:1ug/Test

  • Publishing research using Exonuclease 1? Please let us know so that we can cite the reference in this datasheet.

  • Data sorting...

Choose your product,application and species below,then click "Create".

On the next page you can complete and submit your review.

  • * Code NO.
  • * Application
  • *Sample
  • Species Tested
  • Against
  • Choose text
  • Content

Leave us a review

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols
Add to cart successfully.