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EZH1

Product code: ER1908-44


  • Overview

  • Product name EZH1
  • Molecular Wt 85 KDa
  • Description Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
  • Species reactivity Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
  • Tested applications WB,IHC-P
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen KLH conjugated synthetic peptide derived from human EZH1 471-510/747
  • Positive control 293T(Human) Cell Lysate, Rat lung, Mouse brain.
  • Conjugate Non-conjugated
  • Alternative names Enhancer of zeste homolog 1(Drosophila)
    Enhancer of zeste homolog 1
    ENX-2
    ENX2
    EZH1
    EZH1: enhancer of zeste homolog 1 (Drosophila)
    EZH1_HUMAN
    Histone-lysine N-methyltransferase EZH1
    KIAA0388.
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
  • Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
  • Isotype IgG
  • Purity affinity purified by Protein A
  • Subcellular location Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
  • Database links SwissProt: Q92800 Human
  • Applications

    WB:1:500-2000
    IHC-P:1:400-800

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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