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Nectin 2 [JG39-64]

Product code: ET7108-95

  • Overview

  • Product name Nectin 2
  • Molecular Wt 58 kDa
  • Description Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human nectin is identical to the poliovirus receptor-related protein (PRR) and has been identified as the α-herpesvirus entry mediator. Nectin constitutes a family consisting of at least Nectin 1, 2 and 3; each member has two or three splicing variants. Nectin 2, also designated PRR2/HveB, is ubquitously expressed, with the highest levels of expression in some human neuronal cell lines, fibroblastic cells, keratinocytes and primary activated T lymphocytes. Nectin 2 has two splicing variants, Nectin 2α (short form) and 2δ (long form). Both Nectin 2α and 2δ have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein afadin, through which it is linked to the Actin cytoskeleton. The extracellular regions of the splicing variants are identical, but their transmembrane regions and cytoplasmic regions are unique. Nectin 2 mediates the entry of three mutant herpes simplex virus type 1 (HSV-1) strains that do not use HveA as co-receptor, but not wildtype HSV-1 strains. Nectin 2 also mediates the entry of HSV-2 and pseudorabies virus, but not bovine herpes virus type 1. Nectin 2δ is tyrosine phosphorylated in response to cell-cell adhesion.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC,IF,IHC,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein within human Nectin 2 aa 50-250.
  • Positive control K562, MCF-7, SK-OV-3, LOVO, rat testis tissue, human liver cancer tissue, mouse testis tissue.
  • Conjugate Non-conjugated
  • Clone number JG39-64
  • Alternative names CD 112 antibody
    CD112 antibody
    CD112 antigen antibody
    Herpes virus entry mediator B antibody
    Herpes virus entry protein B antibody
    Herpesvirus entry mediator B antibody
    Herpesvirus entry protein B antibody
    Hve B antibody
    HveB antibody
    Nectin-2 antibody
    Nectin2 antibody
    Poliovirus receptor like 2 antibody
    Poliovirus receptor related 2 (herpesvirus entry mediator B) antibody
    Poliovirus receptor related 2 antibody
    Poliovirus receptor related protein 2 antibody
    Poliovirus receptor-related protein 2 antibody
    PRR 2 antibody
    PRR2 antibody
    PVRL 2 antibody
    PVRL2 antibody
    PVRL2_HUMAN antibody
    PVRR 2 antibody
    PVRR2 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane. Membrane.
  • Database links Q92692(Human)
  • Applications

    WB: 1:500-1:2000
    ICC: 1:50
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • Publishing research using Nectin 2? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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