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CYP27A1 [JG40-36]

Product code: ET7109-05


  • Overview

  • Product name CYP27A1
  • Molecular Wt 60 kDa
  • Description P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endo-genous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased aromatase activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7a-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC,IHC,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein corresponding to human CYP27A1 300-500aa.
  • Positive control Rat heart tissue, human liver tissue, human kidney tissue, human small intestine tissue, HepG2, LOVO.
  • Conjugate Non-conjugated
  • Clone number JG40-36
  • Alternative names 12-alpha-triol 27-hydroxylase antibody
    5-beta-cholestane-3-alpha antibody
    5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase antibody
    5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase antibody
    5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase antibody
    7-alpha antibody
    Cholestanetriol 26 monooxygenase antibody
    CP27 antibody
    CP27A_HUMAN antibody
    CTX antibody
    CYP antibody
    CYP27 antibody
    CYP27A1 antibody
    Cytochrome P 450C27/25 antibody
    Cytochrome P-450C27/25 antibody
    Cytochrome P450 27 antibody
    Cytochrome P450 27 mitochondrial antibody
    Cytochrome P450 family 27 subfamily A member 1 antibody
    Cytochrome P450 family 27 subfamily A polypeptide 1 antibody
    Cytochrome P450 subfamily XXVIIA (steroid 27-hydroxylase cerebrotendinous xanthomatosis) polypeptide 1 antibody
    mitochondrial antibody
    Sterol 26 hydroxylase antibody
    Sterol 26 hydroxylase mitochondrial antibody
    Sterol 26-hydroxylase antibody
    Sterol 27 hydroxylase antibody
    Sterol 27-hydroxylase antibody
    Vitamin D(3) 25 hydroxylase antibody
    Vitamin D(3) 25-hydroxylase antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Mitochondrion membrane.
  • Database links Q02318(Human)
    Q9DBG1(Mouse)
    P17178(Rat)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • Publishing research using CYP27A1? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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