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Transferrin Receptor 2 [JG58-34]

Product code: ET7108-21

  • Overview

  • Product name Transferrin Receptor 2
  • Molecular Wt 89 kDa
  • Description Iron is a vital molecule for living organisms because it is involved in a wide variety of metabolic processes, such as oxygen transport, DNA synthesis and electron transport. Excessive iron uptake leads to tissue damage as a result of formation of free radicals. Iron uptake and storage is tightly regulated by the feedback system of iron responsive element-containing gene products and iron regulatory proteins that modulate the expression levels of the genes involved in iron metabolism. The transferrin receptor 2 (TFR2) mediates the uptake of transferrin-bound iron. It is involved in iron metabolism, hepatocyte function and erythrocyte differentiation, and is highly expressed as a protein in liver as well as in hepatocytes and erythroid precursors. The gene encoding human TRF2 maps to chromosome 7q22 and is expressed as an a isoform, which encodes a transmembrane protein, and a b isoform, which encodes a shorter, intracellular protein. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder that results in clinical complications, including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy and susceptibility to liver cancer.
  • Species reactivity Human
  • Tested applications WB,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein within human Transferrin Receptor 2 aa 100-300.
  • Positive control HepG2, human liver tissue, human liver cancer tissue.
  • Conjugate Non-conjugated
  • Clone number JG58-34
  • Alternative names HFE 3 antibody
    HFE3 antibody
    MGC126368 antibody
    TFR 2 antibody
    TfR2 antibody
    TFR2_HUMAN antibody
    TFRC 2 antibody
    TFRC2 antibody
    Transferrin receptor 2 antibody
    Transferrin receptor protein 2 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A purified.
  • Subcellular location Cell membrane. Cytoplasm.
  • Database links Q9UP52(Human)
  • Applications

    WB: 1:500-1:2,000
    IHC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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