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ALDH4A1 [7E2]

Product code: EM1701-74


  • Overview

  • Product name ALDH4A1
  • Molecular Wt 62 kDa
  • Description Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.
  • Species reactivity Human, Rat
  • Tested applications WB,IHC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Synthetic peptide of C terminal human ALDH4A1.
  • Positive control SK-Br-3, HepG2, human liver tissue, human colon cancer tissue, human prostate tissue, human kidney tissue.
  • Conjugate Non-conjugated
  • Clone number 7E2
  • Alternative names AL4A1_HUMAN antibody
    aldehyde dehydrogenase 4 antibody
    aldehyde dehydrogenase 4 family, member A1 antibody
    Aldehyde dehydrogenase family 4 member A1 antibody
    Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody
    ALDH4 antibody
    aldh4a1 antibody
    Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody
    Delta-1-pyrroline-5-carboxylate dehydrogenase antibody
    L-glutamate gamma-semialdehyde dehydrogenase antibody
    mitochondrial antibody
    mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody
    P5C dehydrogenase antibody
    P5CD antibody
    P5CDh antibody
    P5CDhL antibody
    P5CDhS antibody
    Pyrroline-5-carboxylate dehydrogenase antibody
    RP11 128M10.1 antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG1
  • Purity ProG affinity purified.
  • Subcellular location Mitochondrion.
  • Database links P30038(Human)
    P0C2X9(Rat)
  • Applications

    WB: 1:1,000-1:2,000
    IHC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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