Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.
Mouse Monoclonal Antibody
Synthetic peptide of C terminal human ALDH4A1.
SK-Br-3, HepG2, human liver tissue, human colon cancer tissue, human prostate tissue, human kidney tissue.
aldehyde dehydrogenase 4 antibody
aldehyde dehydrogenase 4 family, member A1 antibody
Aldehyde dehydrogenase family 4 member A1 antibody
Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody
Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody
Delta-1-pyrroline-5-carboxylate dehydrogenase antibody
L-glutamate gamma-semialdehyde dehydrogenase antibody
mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody
P5C dehydrogenase antibody
Pyrroline-5-carboxylate dehydrogenase antibody
RP11 128M10.1 antibody
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
ProG affinity purified.
Fig1: Western blot analysis of ALDH4A1 on SK-Br-3 (1) and HepG2 (2) cell lysate using anti-ALDH4A1 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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