GABA A Receptor alpha 5
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.
Human, Mouse, Rat
Recombinant Rabbit Monoclonal Antibody
A549 cell lysate, 293T cell lysate, rat brain tissue lysate, SH-SY-5Y cell, 293T cell, A549 cell, rat brain tissue, mouse brain tissue.
GAA 5 antibody
GABA(A) receptor subunit alpha-5 antibody
GABRA 5 antibody
Gamma aminobutyric acid GABA A receptor alpha 5 antibody
Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody
Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody
Gamma-aminobutyric acid receptor subunit alpha-5 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
SwissProt: P31644 Human
SwissProt: Q8BHJ7 Mouse
SwissProt: P19969 Rat
Fig1: Western blot analysis of GABA A Receptor alpha 5 on different lysates using anti-GABA A Receptor alpha 5 antibody at 1/1,000 dilution.
Lane 1: A549 cell lysate
Lane 2: 293T cell lysate
Lane 3: Rat brain tissue lysate
Fig2: ICC staining GABA A Receptor alpha 5 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining GABA A Receptor alpha 5 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: ICC staining GABA A Receptor alpha 5 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-GABA A Receptor alpha 5 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-GABA A Receptor alpha 5 antibody. Counter stained with hematoxylin.
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