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GABA A Receptor alpha 5 [JB34-19]

Product code: ET7107-08

  • Overview

  • Product name GABA A Receptor alpha 5
  • Molecular Wt 52 kDa
  • Description Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABAA receptor. At least 16 distinct subunits of GABAA receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. Recent research has produced several ligands which are moderately selective for GABAA receptors containing the α5 subunit. These have proved to be useful in investigating some of the side effects of benzodiazepine and nonbenzodiazepine drugs, particularly the effects on learning and memory such as anterograde amnesia. Inverse agonists at this subunit have nootropic effects and may be useful for the treatment of cognitive disorders such as Alzheimer's disease.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC,IF,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein.
  • Positive control A549 cell lysate, 293T cell lysate, rat brain tissue lysate, SH-SY-5Y cell, 293T cell, A549 cell, rat brain tissue, mouse brain tissue.
  • Conjugate Non-conjugated
  • Clone number JB34-19
  • Alternative names GAA 5 antibody
    GAA5 antibody
    GABA(A) receptor subunit alpha-5 antibody
    GABRA 5 antibody
    Gabra5 antibody
    Gamma aminobutyric acid GABA A receptor alpha 5 antibody
    Gamma aminobutyric acid GABA A receptor alpha 5 precursor antibody
    Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor antibody
    Gamma-aminobutyric acid receptor subunit alpha-5 antibody
    GBRA5_HUMAN antibody
    GC138184 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A purified.
  • Subcellular location Plasma membrane.
  • Database links SwissProt: P31644 Human
    SwissProt: Q8BHJ7 Mouse
    SwissProt: P19969 Rat
  • Applications

    WB: 1:500-1:2,000
    ICC/IF: 1:50-1:200
    IHC: 1:50-1:200

  • Publishing research using GABA A Receptor alpha 5? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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