The synuclein family members, including α-synuclein (also designated NACP for non-β-Amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation α-synuclein has been found to be upregulated, while β-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson's disease.
Recombinant Rabbit Monoclonal Antibody
Hela, SH-SY-5Y, human fetal brain tissue lysate, mouse brain tissue.
Alpha synuclein antibody
Alpha-synuclein, isoform NACP140 antibody
Non A beta component of AD amyloid antibody
Non A4 component of amyloid antibody
Non A4 component of amyloid precursor antibody
Non-A beta component of AD amyloid antibody
Non-A-beta component of alzheimers disease amyloid , precursor of antibody
Non-A4 component of amyloid precursor antibody
Non-A4 component of amyloid, precursor of antibody
PARK 1 antibody
PARK 4 antibody
Parkinson disease (autosomal dominant, Lewy body) 4 antibody
Parkinson disease familial 1 antibody
Snca synuclein, alpha (non A4 component of amyloid precursor) antibody
Synuclein alpha antibody
Synuclein alpha 140 antibody
Synuclein, alpha (non A4 component of amyloid precursor) antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Nucleus. Cytoplasm. Secreted. Membrane.
Fig1: Western blot analysis of Alpha Synuclein on human fetal brain tissue lysate using anti-Alpha Synuclein antibody at 1/500 dilution.
Fig2: ICC staining Alpha Synuclein in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Alpha Synuclein antibody. Counter stained with hematoxylin.
Fig4: Flow cytometric analysis of SH-SY-5Y cells with Alpha Synuclein antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
1. Waxman E A et al. Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. Biochemistry 48:9427-9436 (2009).
2. Krueger R et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18:106-108 (1998).
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