Alpha-1 acid glycoprotein
AGP (α1-acid glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.
Human, Mouse, Rat
Rabbit Polyclonal Antibody
Human liver tissue lysates, rat liver tissue, human liver tissue, mouse liver tissue, HepG2.
AGP 1 antibody
AGP A antibody
Alpha 1 acid glycoprotein antibody
Alpha-1-acid glycoprotein 1 antibody
Epididymis secretory sperm binding protein Li 153w antibody
glycoprotein, alpha-1-acid, of serum antibody
HEL S 153w antibody
OMD 1 antibody
Orosomucoid 1 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified
Fig1: Western blot analysis of Alpha-1 Acid Glycoprotein on human liver tissue lysates using anti-Alpha-1 acid glycoprotein antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of HepG2 cells with Alpha-1 Acid Glycoprotein antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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