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PCK1 [JU84-39]

Product code: ET7106-81


  • Overview

  • Product name PCK1
  • Molecular Wt 69 kDa
  • Description Normal adjustment to changes in blood glucose levels depends on insulin signaling as well as enzymes involved in the regulation of gluconeogenesis. Pathological changes to this process are central to the type 2 diabetes phenotype. Phosphoenolpyruvate carboxykinase (PEPCK) plays an important role in this process by stimulating hepatic glucose production. PEPCK expression increases in response to glucagon and glucocorticoids, while insulin suppresses expression. Modulation of the signals governing PEPCK levels present a potential therapeutic approach to the treatment of insulin resistance and consequently obesity. The cytosolic form of PEPCK, known as PEPCK-C, and the mitochondrial form, known as PEPCK-M, are encoded by two different nuclear genes in mouse, human and chicken.
  • Species reactivity Human
  • Tested applications ICC,IHC,WB
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control 293T, HepG2, SH-SY5Y, human liver tissue, human kidney tissue.
  • Conjugate Non-conjugated
  • Clone number JU84-39
  • Alternative names cytosolic [GTP] antibody
    GTP antibody
    PCK1 antibody
    PCKGC_HUMAN antibody
    PEP carboxykinase antibody
    PEPCK-C antibody
    PEPCK1 antibody
    PEPCKC antibody
    Phosphoenolpyruvate carboxykinase 1 (soluble) antibody
    Phosphoenolpyruvate carboxykinase 1 antibody
    Phosphoenolpyruvate carboxykinase antibody
    Phosphoenolpyruvate carboxykinase, cytosolic [GTP] antibody
    Phosphoenolpyruvate carboxykinase, cytosolic antibody
    Phosphoenolpyruvate carboxylase antibody
    Phosphopyruvate carboxylase antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm.
  • Database links P35558(Human)
  • Applications

    ICC: 1:50-1:200
    IHC: 1:50-1:200
    WB: 1:500

  • Publishing research using PCK1? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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