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BDKRB2 [JU39-04]

Product code: ET7106-74


  • Overview

  • Product name BDKRB2
  • Molecular Wt 80 kDa
  • Description Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.
  • Species reactivity Human, Mouse
  • Tested applications WB,FC,IP
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control MCF-7, SH-SY5Y.
  • Conjugate Non-conjugated
  • Clone number JU39-04
  • Alternative names B2 antibody
    B2 bradykinin receptor antibody
    B2BKR antibody
    B2BRA antibody
    B2R antibody
    BDKR B2 antibody
    BDKRB 2 antibody
    BDKRB2 antibody
    BK 2 antibody
    BK 2 receptor antibody
    BK R2 antibody
    BK-2 receptor antibody
    BK2 antibody
    BK2 receptor antibody
    BK2R antibody
    BKR 2 antibody
    BKR2 antibody
    BKRB2_HUMAN antibody
    BR B2 antibody
    Bradykinin receptor B2 antibody
    Bradykinin receptor beta 2 antibody
    BRB 2 antibody
    BRB2 antibody
    DKFZp686O088 antibody
    Kinin B2 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane.
  • Database links P30411(Human)
  • Applications

    WB: 1:500-1:1,000
    FC: 1:50-1:100
    IP: 1:10-1:50

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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