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ADAR [JU99-33]

Product code: ET7106-72

  • Overview

  • Product name ADAR
  • Molecular Wt 136 kDa
  • Description RNA-specific adenosine deaminase (ADAR1, DSH, IFI4, p136, DRADA, DSRAD, K88dsRBP) mediates RNA editing by destabilizing double stranded RNA through deamination of adenosine to inosine in structured or double-stranded RNAs. ADAR1 is expressed from an interferon-response promoter and has a Z-DNA/Z-RNA binding domain at its N-terminus. ADAR1 co-localizes with SUMO-1 in a subnucleolar region that is distinct from the fibrillar center, the dense fibrillar component and the granular component. Localization of nuclear ADAR1 is under the influence of a nucleolar localization signal (NoLS) in the middle of ADAR1 and the exporting activity of the nuclear exporter signal (NES) near the N terminus. ADAR1 upregulates nuclear factor 90 (NF90)-mediated gene expression by interacting with NF110, NF90 and NF45. ADAR1 binds short interfering RNA (siRNA), and gene silencing by siRNA is significantly more effective in mouse fibroblasts homozygous for an ADAR1 null mutation than in wild-type cells. ADAR1 may limit the efficacy of siRNA in mammalian cells.
  • Species reactivity Human
  • Tested applications WB,ICC,IF,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Hela, human lung cancer tissue, human colon cancer tissue, human kidney tissue, human pancreas tissue, SiHa.
  • Conjugate Non-conjugated
  • Clone number JU99-33
  • Alternative names 136 kDa double-stranded RNA-binding protein antibody
    136kDa double stranded RNA binding protein antibody
    Adar 1 antibody
    ADAR antibody
    Adar1 antibody
    Adenosine deaminase acting on RNA 1 A antibody
    Adenosine deaminase RNA specific 1 antibody
    Adenosine deaminase RNA specific antibody
    Adenosine deaminase that act on RNA antibody
    AGS6 antibody
    AV242451 antibody
    Double stranded RNA specific adenosine deaminase antibody
    Double-stranded RNA-specific adenosine deaminase antibody
    Double-stranded RNA-specific editase Adar antibody
    DRADA antibody
    Dsh antibody
    Dsrad antibody
    DSRAD_HUMAN antibody
    dsRNA adenosine deaminase antibody
    EC 3.5.4.- antibody
    G1P1 antibody
    IFI 4 antibody
    IFI-4 antibody
    IFI4 antibody
    Ifi4 protein antibody
    Interferon induced protein 4 antibody
    Interferon inducible protein 4 antibody
    Interferon-inducible protein 4 antibody
    K88DSRBP antibody
    mZaADAR antibody
    P136 antibody
    Pre-mRNA adenosine deaminase antibody
    RNA adenosine deaminase 1 antibody
    RNA-editing deaminase 1 antibody
    RNA-editing enzyme 1 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm. Nucleus.
  • Database links P55265(Human)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200

  • Publishing research using ADAR? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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