Location: Home >Product >Product Detail


Product code: ER1706-64

  • Overview

  • Product name 4E-BP1
  • Molecular Wt  12.5 kDa
  • Description The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC,IHC,FC
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen Recombinant protein.
  • Positive control Mouse placenta tissue, PC-3M, 293T, rat esophagus tissue, human tonsil tissue, human pancreas tissue, mouse small intestine tissue.
  • Conjugate Non-conjugated
  • Alternative names 4E-BP1 antibody
    4EBP1 antibody
    4EBP1_HUMAN antibody
    BP 1 antibody
    eIF4E binding protein 1 antibody
    eIF4E-binding protein 1 antibody
    Eif4ebp1 antibody
    Eukaryotic translation initiation factor 4E-binding protein 1 antibody
    PHAS-I antibody
    PHASI antibody
    Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein affinity purified.
  • Subcellular location Cytoplasm. Nucleus.
  • Database links Q13541(Human)
  • Applications

    WB: 1:500-1:1,000
    ICC: 1:500-1:1,000
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • Publishing research using 4E-BP1? Please let us know so that we can cite the reference in this datasheet.

  • Data sorting...

Choose your product,application and species below,then click "Create".

On the next page you can complete and submit your review.

  • * Code NO.
  • * Application
  • *Sample
  • Species Tested
  • Against
  • Choose text
  • Content

Leave us a review

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols
Add to cart successfully.