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4E-BP1

Product code: ER1706-64


  • Overview

  • Product name 4E-BP1
  • Molecular Wt  12.5 kDa
  • Description The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC,IHC,FC
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen Recombinant protein.
  • Positive control Mouse placenta tissue, PC-3M, 293T, rat esophagus tissue, human tonsil tissue, human pancreas tissue, mouse small intestine tissue.
  • Conjugate Non-conjugated
  • Alternative names 4E-BP1 antibody
    4EBP1 antibody
    4EBP1_HUMAN antibody
    BP 1 antibody
    eIF4E binding protein 1 antibody
    eIF4E-binding protein 1 antibody
    Eif4ebp1 antibody
    Eukaryotic translation initiation factor 4E-binding protein 1 antibody
    PHAS-I antibody
    PHASI antibody
    Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein affinity purified.
  • Subcellular location Cytoplasm. Nucleus.
  • Database links Q13541(Human)
    Q60876(Mouse)
    Q62622(Rat)
  • Applications

    WB: 1:500-1:1,000
    ICC: 1:500-1:1,000
    IHC: 1:50-1:200
    FC: 1:50-1:100

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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