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Fragilis [JU73-02]

Product code: ET1706-09

  • Overview

  • Product name Fragilis
  • Molecular Wt 15 kDa
  • Description IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
  • Species reactivity Human
  • Tested applications WB,ICC/IF,IHC,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Hela, HepG2, HUVEC, MCF-7, PC-3M, human liver cancer tissue, human colon cancer tissue.
  • Conjugate Non-conjugated
  • Clone number JU73-02
  • Alternative names 1 8U antibody
    Fragilis antibody
    IFITM3 antibody
    IFM3_HUMAN antibody
    Interferon induced transmembrane protein 3 (1 8U) antibody
    Interferon Induced Transmembrane Protein 3 antibody
    Interferon inducible antibody
    Interferon inducible protein 1 8U antibody
    Interferon Inducible Protein 15 antibody
    Interferon Inducible Protein Homolog antibody
    Interferon-induced transmembrane protein 3 antibody
    Interferon-inducible protein 1-8U antibody
    IP15 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane. Lysosome.
  • Database links Q01628(Human)
  • Applications

    WB: 1:1,000-1:5,000
    ICC: 1:50-1:200
    IHC: 1:50-1:100
    FC: 1:50-1:100

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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