SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females.
Mouse Monoclonal Antibody
Human SRY recombinant protein, NTERA-2, human cervical cancer tissue, human ovarian cancer tissue, HepG2.
Essential protein for sex determination in human males antibody
Sex determining region on Y antibody
Sex determining region protein antibody
Sex determining region Y antibody
Sex-determining region Y protein antibody
SRY 1 antibody
Testis determining factor antibody
Testis Determining Factor on Y antibody
Testis-determining factor antibody
Transcription factor Sox-21-B antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
ProA affinity purified
Nucleus speckle. Cytoplasm.
Fig1: Western blot analysis of SRY on human SRY recombinant protein using anti-SRY antibody at 1/1,000 dilution.
Fig2: Western blot analysis of SRY on NTERA-2 cell lysate using anti-SRY antibody at 1/1,000 dilution.
Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of HepG2 cells with SRY antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
1. Wang, J et al. Bone mesenchymal stem cells overexpressing FGF4 contribute to liver regeneration in an animal model of liver cirrhosis. International journal of clinical and experimental medicine 8: 12774-82 (2015).
2. Yannaki, E et al. G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Exp Hematol 33: 108-119 (2005).
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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