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Protein FAM38A [2-10]

Product code: M1005-2

  • Overview

  • Product name Protein FAM38A
  • Molecular Wt 287 kDa
  • Description Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.
  • Species reactivity Human, Mouse
  • Tested applications WB,IHC,ICC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein.
  • Positive control Recombinant protein, mouse brain tissue, A431.
  • Conjugate Non-conjugated
  • Clone number 2-10
  • Alternative names DHS
    Family with sequence similarity 38 member A
    Membrane protein induced by beta-amyloid treatment
    Piezo-type mechanosensitive ion channel component 1
    Protein FAM38A
    Protein FAM38B
    Protein PIEZO1
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG2a
  • Purity ProA affinity purified
  • Subcellular location Endoplasmic reticulum membrane. Cell membrane.
  • Database links Q92508(Human)
  • Applications

    WB: 1:500-1:2,000

    IHC: 1:50-1:200

    ICC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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