Transmembrane glycoprotein NMB (GPNMB), also designated hematopoietic growth factor inducible neurokinin-1 (HGFIN), is a single-pass type I membrane protein. Belonging to the Pmel-17/NMB family of proteins, GPNMB acts as a melanogenic enzyme. GPNMB expression is not restricted to cells of melanocytic lineage and is highest in poorly metastatic melanoma cell lines. There is no expression of GPNMB in highly metastatic melanoma cell lines. GPNMB may play a important role in lymphohematopoietic stem cell maturation.
Mouse Monoclonal Antibody
Human GPNMB recombinant protein, GPNMB-hIgGFc transfected HEK293 cell lysate, PANC-1, PC-3 cell lysate, human breast cancer tissue, human esophagus cancer tissue.
Glycoprotein (transmembrane) nmb antibody
Glycoprotein nmb antibody
Glycoprotein nmb like protein antibody
Transmembrane glycoprotein antibody
Transmembrane glycoprotein HGFIN antibody
Transmembrane glycoprotein NMB antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Fig1: Western blot analysis of GPNMB on human GPNMB recombinant protein using anti-GPNMB antibody at 1/1,000 dilution.
Fig2: Western blot analysis of GPNMB on HEK293 (1) and GPNMB-hIgGFc transfected HEK293 (2) cell lysate using anti-GPNMB antibody at 1/1,000 dilution.
Fig3: Western blot analysis of GPNMB on PANC-1 and PC-3 cell lysate using anti-GPNMB antibody at 1/1,000 dilution.
Fig4: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.
1. Tsui KH et al. Glycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells. Prostate 72(13):1431-42 (2012).
2. Williams MD et al. GPNMB expression in uveal melanoma: a potential for targeted therapy. Melanoma Res 20(3):184-90 (2010).
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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