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NR1I2 [G1-D12]

Product code: EM1708-18

  • Overview

  • Product name NR1I2
  • Molecular Wt 50 kDa
  • Description Steroid hormones function as signaling molecules by diffusing into cells and interacting with specific intracellular receptors to regulate gene expression. This superfamily of receptors includes both steroid and nonsteroid receptors. Like many nonsteroid hormone receptors, PXR (Pregnane X Receptor) binds as a heterodimer with RXR to a DNA sequence typical of a nonsteroid hormone receptor; however, PXR is activated by several steroids, such as naturally occurring pregnanes and synthetic glucocorticoids and anti- glucocorticoids. PXR exists as two alternatively spliced isoforms, PXR.1 and PXR.2. PXR is thought to define a novel steroid hormone signaling pathway that may account for some of the effects of synthetic glucocorticoids and antiglucocorticoids that are not mediated through the classical glucocorticoid receptor signaling pathway.
  • Species reactivity Human
  • Tested applications WB,ICC,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Human NR1I2 recombinant protein, NR1I2-hIgGFc transfected HEK293 cell lysate, Hela, HepG2.
  • Conjugate Non-conjugated
  • Clone number G1-D12
  • Alternative names BXR antibody
    Nr1i2 antibody
    NR1I2_HUMAN antibody
    Nuclear receptor subfamily 1 group I member 2 antibody
    ONR 1 antibody
    ONR1 antibody
    Orphan nuclear receptor PAR 1 antibody
    Orphan nuclear receptor PAR1 antibody
    Orphan nuclear receptor PXR antibody
    OTTHUMP00000215173 antibody
    OTTHUMP00000215174 antibody
    OTTHUMP00000215175 antibody
    PAR 1 antibody
    PAR 2 antibody
    PAR antibody
    PAR q antibody
    PAR1 antibody
    PAR2 antibody
    PARq antibody
    pregnane X nuclear receptor variant 2 antibody
    Pregnane X receptor antibody
    PRR antibody
    PXR antibody
    SAR antibody
    Steroid and xenobiotic receptor antibody
    SXR antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG2b
  • Purity ProA affinity purified
  • Subcellular location Nucleus,intermediate filament cytoskeleton.
  • Database links O75469(Human)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    FC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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