Glucose Transporter GLUT3
Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. Glut1, Glut3 and Glut4 are high-affinity transporters, whereas Glut2 is a low-affinity transporter. In adipose and muscle tissue, Insulin stimulates a rapid and dramatic increase in glucose uptake, largely due to the redistribution of the Insulin-inducible glucose transporter, Glut4. In response to Insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to Insulin. Glut2 expression is seen in pancreatic b cells, hepatocytes and basolateral membranes of intestinal and epithelial cells, while the highest expression of Glut3 has been found in neuronal tissue.
Human, Mouse, Rat
Recombinant Rabbit Monoclonal Antibody
Human lung tissue lysate, HepG2 cell lysate, mouse heart tissue lysate, human brain tissue, human embryo tissue, mouse brain tissue, SH-SY5Y.
Glucose transporter type 3 antibody
Glucose transporter type 3 brain antibody
GLUT 3 antibody
Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3 antibody
Solute carrier family 2, facilitated glucose transporter member 3 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Cell membrane. Multi-pass membrane protein.
Fig1: Western blot analysis of Glucose Transporter GLUT3 on different cell lysate using anti-Glucose Transporter GLUT3 antibody at 1/1,000 dilution. Positive control：
Lane1: Human lung
Lane3: Mouse heart
Fig2: Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Glucose Transporter GLUT3 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human embryo tissue using anti-Glucose Transporter GLUT3 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Glucose Transporter GLUT3 antibody. Counter stained with hematoxylin.
Fig5: Flow cytometric analysis of SH-SY5Y cells with Glucose Transporter GLUT3 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
1. Zhu Y?et al.?An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis.?PLoS Pathog?12:e1005648 (2016).
2. Tu H et al.?Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid.?EBioMedicine?2:1735-50 (2015).
Publishing research using Glucose Transporter GLUT3? Please let us know so that we can cite the reference in this datasheet.
Choose your product,application and species below,then click "Create".
On the next page you can complete and submit your review.
Leave us a review
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Click here to view the general protocols