May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.
Mouse Monoclonal Antibody
Human IL1RAPL1 recombinant protein, IL1RAPL1-hIgGFc transfected HEK293 cell lysate, A431, SK-Hep-1, HL-7702, Hela.
IL 1 RAPL 1 antibody
IL 1RAPL 1 antibody
IL1RAPL 1 antibody
Interleukin 1 receptor 8 antibody
Interleukin 1 receptor accessory protein like 1 antibody
Interleukin-1 receptor accessory protein-like 1 antibody
Mental retardation X linked 10 antibody
Mental retardation X linked 21 antibody
Mental retardation X linked 34 antibody
MRX 21 antibody
MRX 34 antibody
Oligophrenin 4 antibody
OPHN 4 antibody
Three immunoglobulin domain containing IL 1 receptor related 2 antibody
Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody
TIGIRR 2 antibody
X linked interleukin 1 receptor accessory protein like 1 antibody
X-linked interleukin-1 receptor accessory protein-like 1 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Cell membrane. Cytoplasm.
WB: 1:500-1:2,000 ICC: 1:50-1:200 FC: 1:100-1:200
Fig1: Western blot analysis of IL1RAPL1 on ?human IL1RAPL1 recombinant protein using anti-IL1RAPL1 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of IL1RAPL1 on HEK293 (1) and IL1RAPL1-hIgGFc transfected HEK293 (2) cell lysate using anti-IL1RAPL1 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of IL1RAPL1 on different cell lysate using anti-IL1RAPL1 antibody at 1/1,000 dilution. Positive control： Lane1: A431 Lane2: SK-Hep-1 Lane3: HL-7702
Fig4:ICC staining IL1RAPL1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig5: Flow cytometric analysis of Hela cells with IL1RAPL1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
1. Montani C et al. The X-Linked Intellectual Disability Protein?IL1RAPL1?Regulates Dendrite Complexity.J Neurosci 37(28):6606-6627 (2017). 2. Laino L et al. Clinical and molecular characterization of a boy with intellectual disability, facial dysmorphism, minor digital anomalies and a complex?IL1RAPL1?intragenic rearrangement.Eur J Paediatr Neurol 20(6):971-976 (2015).
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