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TTF1 [D8-F4]

Product code: EM1707-55

  • Overview

  • Product name TTF1
  • Molecular Wt 103 kDa
  • Description This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
  • Species reactivity Human
  • Tested applications WB,ICC,IHC,FC
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Recombinant protein
  • Positive control Human TTF1 recombinant protein, TTF1-hIgGFc transfected HEK293 cell lysate, MCF-7, SK-OV-3, Hela, human rectum cancer tissue, human cervical cancer tissue.
  • Conjugate Non-conjugated
  • Clone number D8-F4
  • Alternative names AV026640 antibody
    BCH antibody
    Benign chorea antibody
    BHC antibody
    Homeobox protein NK 2 homolog A antibody
    Homeobox protein NK-2 homolog A antibody
    Homeobox protein Nkx 2.1 antibody
    Homeobox protein Nkx-2.1 antibody
    Homeobox protein Nkx2.1 antibody
    NK 2 antibody
    NK 2 homolog A antibody
    NK2 antibody
    NK2 homeobox 1 antibody
    NK2, drosophila, homolog of, A antibody
    NK2.1, mouse, homolog of antibody
    Nkx 2 1 antibody
    NKX 2.1 antibody
    NKX 2A antibody
    NKX2 1 antibody
    Nkx2-1 antibody
    NKX2.1 antibody
    NKX21_HUMAN antibody
    NKX2A antibody
    T EBP antibody
    T/EBP antibody
    TEBP antibody
    Thyroid nuclear factor 1 antibody
    Thyroid nuclear factor antibody
    Thyroid specific enhancer binding protein antibody
    Thyroid transcription factor 1 antibody
    Tin man antibody
    Tinman antibody
    TITF 1 antibody
    TITF1 antibody
    TTF 1 antibody
    TTF-1 antibody
    TTF1 antibody
  • Properties

  • Form Liquid
  • Concentration 2 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG1
  • Purity ProA affinity purified
  • Subcellular location Nucleus
  • Database links Q15361(Human)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:200

  • Publishing research using TTF1? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols
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