b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.
Human, Mouse, Rat
Recombinant Rabbit Monoclonal Antibody
SW480, mouse colon tissue, mouse brain tissue.
Axin like protein antibody
Axin-like protein antibody
Axis inhibition protein 2 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Fig1: Western blot analysis of Axin2 on SW480 cells lysates using anti-Axin2 antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Axin2 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Axin2 antibody. Counter stained with hematoxylin.
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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