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Axin2 [JM11-30]

Product code: ET1703-96


  • Overview

  • Product name Axin2
  • Molecular Wt 94 kDa
  • Description b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC/IF,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control SW480, mouse colon tissue, mouse brain tissue.
  • Conjugate Non-conjugated
  • Clone number JM11-30
  • Alternative names Axil antibody
    Axin like protein antibody
    Axin-2 antibody
    Axin-like protein antibody
    Axin2 antibody
    AXIN2_HUMAN antibody
    Axis inhibition protein 2 antibody
    Conductin antibody
    DKFZp781B0869 antibody
    MGC10366 antibody
    MGC126582 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm.
  • Database links Q9Y2T1(Human)
    O88566(Mouse)
    O70240(Rat)
  • Applications

    WB: 1:500-1:2,000
    ICC: 1:50-1:200
    IHC: 1:10-1:50

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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