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Cyclophilin A [JM107-03]

Product code: ET1703-33


  • Overview

  • Product name Cyclophilin A
  • Molecular Wt 18 kDa
  • Description The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control Hela, HepG2, A431, human breast carcinoma tissue, human lung tissue, human pancreas tissue, mouse lung tissue.
  • Conjugate Non-conjugated
  • Clone number JM107-03
  • Alternative names Cyclophilin A antibody
    Cyclophilin antibody
    CyclophilinA antibody
    Cyclosporin A binding protein antibody
    Cyclosporin A-binding protein antibody
    CYPA antibody
    CYPH antibody
    Epididymis secretory sperm binding protein Li 69p antibody
    HEL S 69p antibody
    MGC117158 antibody
    MGC12404 antibody
    MGC23397 antibody
    Peptidyl prolyl cis trans isomerase A antibody
    Peptidyl-prolyl cis-trans isomerase A antibody
    Peptidylprolyl isomerase A (cyclophilin A) antibody
    Peptidylprolyl isomerase A antibody
    PPIA antibody
    PPIA protein antibody
    PPIA_HUMAN antibody
    PPIase A antibody
    Rotamase A antibody
    RotamaseA antibody
    T cell cyclophilin antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, secreted.
  • Database links P62937(Human)
    P17742(Mouse)
    P10111
    (Rat)
  • Applications

    WB: 1:1,000-1:5,000
    IHC: 1:50-1:200

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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