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Prion Protein(PrP) [SC57-05]

Product code: ET1610-27


  • Overview

  • Product name Prion Protein(PrP)
  • Molecular Wt 28 kDa
  • Description Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Characteristic of prion diseases, cellular PrP (PrPc) is converted to the disease form, PrPSc, through alterations in the protein folding conformations. PrPc is constitutively expressed in normal adult brain and is sensitive to proteinase K digestion, while the altered PrPSc conformation is resistant to proteases, resulting in a distinct molecular mass after PK treatment. Consistent with the transient infection process of prion diseases, incubation of PrPc with PrPSc both in vitro and in vivo produces PrPc that is resistant to protease degradation. Infectious PrPSc is found at high levels in the brains of animals affected by TSEs, including scrapie in sheep, BSE in cattle and Cruetzfeldt-Jakob disease in humans.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB,ICC/IF,IHC,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control N2A, SHG-44, SH-SY-5Y, rat brain tissue, mouse brain tissue.
  • Conjugate Non-conjugated
  • Clone number SC57-05
  • Alternative names Alternative prion protein; major prion protein antibody
    AltPrP antibody
    ASCR antibody
    CD230 antibody
    CD230 antigen antibody
    CJD antibody
    GSS antibody
    KURU antibody
    Major prion protein antibody
    p27 30 antibody
    PRIO_HUMAN antibody
    Prion protein antibody
    Prion related protein antibody
    PRIP antibody
    PRNP antibody
    PrP antibody
    PrP27 30 antibody
    PrP27-30 antibody
    PrP33-35C antibody
    PrPC antibody
    PrPSc antibody
    Sinc antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Nucleus, Cell membrane.
  • Database links P04156(Human)
    P04925(Mouse)
    P13852(Rat)
  • Applications

    WB: 1:1,000-1:5,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200
    FC: 1:50-1:100

  • Publishing research using Prion Protein(PrP)? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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