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S100 beta [SC57-02]

Product code: ET1610-3

  • Overview

  • Product name S100 beta
  • Molecular Wt 11 kDa
  • Description The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbuminβ(also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 α chain and S-100 β chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two α chains, two β chains or one α and one β chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 α and β are present in a variety of other tissues, and calbindin is present in intestine and kidney.
  • Species reactivity Human, Mouse, Rat, Goat, zebrafish
  • Tested applications WB,ICC/IF,IP,IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control N2A, SH-SY-5Y, Hela, HepG2, mouse brain tissue.
  • Conjugate Non-conjugated
  • Clone number SC57-02
  • Alternative names NEF antibody
    Protein S100 B antibody
    Protein S100-B antibody
    S 100 calcium binding protein beta chain antibody
    S 100 protein beta chain antibody
    S-100 protein beta chain antibody
    S-100 protein subunit beta antibody
    S100 antibody
    S100 calcium binding protein beta (neural) antibody
    S100 calcium-binding protein B antibody
    S100 protein beta chain antibody
    S100B antibody
    S100B_HUMAN antibody
    S100beta antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cytoplasm, Nucleus.
  • Database links P04271(Human)
  • Applications

    WB: 1:1,000-1:5,000
    ICC: 1:50-1:200
    IHC: 1:50-1:200

  • Publishing research using S100 beta? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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