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PBR [SA90-03]

Product code: ET1601-19

  • Overview

  • Product name PBR
  • Molecular Wt 19 kDa
  • Description Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR. The polypeptide diazepam binding inhibitor is an endogenous PBR ligand. PBR also binds Ro 5-4864 (4’-chlorodiazepam) and PK 11185 (an isoquinoline carboxamide derivative), but not clonazepam, and PBR regulates the cholesterol transport that results in decreased circulating corticosterone levels.
  • Species reactivity Human, Mouse
  • Tested applications WB,ICC/IF,IHC-P,IP,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Synthetic peptide within C-terminal human PBR.
  • Positive control 293T cell lysate, NIH/3T3 cell lysate, HepG2 cell lysate, Hela, PC-3M, SW480, human colon carcinoma tissue, human kidney tissue, mouse testis tissue, mouse kidney tissue.
  • Conjugate Non-conjugated
  • Clone number SA90-03
  • Alternative names Benzodiazapine receptor (peripheral) antibody
    Benzodiazepine peripheral binding site antibody
    BPBS antibody
    BZRP antibody
    DBI antibody
    IBP antibody
    Isoquinoline carboxamide-binding protein antibody
    MBR antibody
    mDRC antibody
    Mitochondrial benzodiazepine receptor antibody
    PBR antibody
    PBS antibody
    Peripheral benzodiazepine receptor antibody
    Peripheral benzodiazepine receptor-related protein antibody
    Peripheral type benzodiazepine receptor antibody
    Peripheral-type benzodiazepine receptor antibody
    pk18 antibody
    PKBS antibody
    PTBR antibody
    Ptbzr antibody
    PTBZR02 antibody
    RATPTBZR02 antibody
    translocator protein (18kDa) antibody
    Translocator protein antibody
    Tspo antibody
    Tspo1 antibody
    TSPOA_HUMAN antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A affinity purified.
  • Subcellular location Mitochondrion membrane
  • Database links SwissProt: P30536 Human
    SwissProt: P50637 Mouse
  • Applications

    WB: 1:500-1:5,000
    ICC/IF: 1:50-1:200
    IHC-P: 1:50-1:200
    FC: 1:50-1:100
    IP: Use at an assay dependent concentration.

  • Publishing research using PBR? Please let us know so that we can cite the reference in this datasheet.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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